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P-glycoprotein (P-gp) is a transmembrane protein that functions to expel cytotoxic drugs from the cell. Some breast cancers have shown a link between P-gp expression and treatment outcome. This study was performed to assess P-gp expression in breast cancer patients, and to examine its prognostic value in the initial and metastatic stages of breast cancer. We assessed P-gp expression by immunohistochemistry in primary (n=150) and metastatic (n=80) breast cancer samples using the monoclonal antibody C219. All the specimens were estrogen and progesterone receptor-positive. Of the 606 breast cancer patients (311 primary and 295 metastatic), 68 (11.2%) were P-gp-positive. Positive P-gp expression was found in 8% (n=16) of the primary breast cancers and 11% (n=13) of the metastatic breast cancers. There was no significant association between positive P-gp expression and either the age or the stage of the patients, or the histological subtypes of the cancers. Positive P-gp expression was found in 11.5% of triple-negative breast cancers. The survival analysis showed that the positive P-gp expression group had a ac619d1d87
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